Primary Immunization of Rh-negative Volunteers

Primary immunization of Rh-negative volunteers.

To determine the best method for the production of high-titre anti-D serum primary immunization was carried out in two groups of Rh-negative male volunteers with washed group O R(2)R(2) cells. The first group of six men were given 5 ml. of packed cells, and the second group of five men were given 0.5 ml. of packed cells, in each instance by intravenous injection. Only one individual in each gro...

Factors Influencing the Immunization of Rh - negative Mothers

According to Nevanlinna and Vainio (1962) the probability that an Rh-negative mother who has had two Rh-positive children will be immunized is 4-5%. In the third and later births the probability of immunization decreases rapidly. The reason why most mothers do not become immunized is intriguing. It may depend on individual differences in immunological reactivity, and perhaps the response of som...

Further factors influencing Rh-immunization: II.

Abo Blood Groups and Rh Iso-immunization.

Levine (1943, 1958a, b, 1959) observed that Rh isoimmunization of Rh-negative women was relatively much morecommon inwomen with ABO-compatible husbands than in women with ABO-incompatible husbands. This observation has implications with regard to the incidence of the ABO blood groups in affected families, and certain of these implications were first noted by Lucia and Hunt (1950a, b) in respect...

Human Rh D monoclonal antibodies (BRAD-3 and BRAD-5) cause accelerated clearance of Rh D+ red blood cells and suppression of Rh D immunization in Rh D- volunteers.

The use of prophylactic anti-D to prevent Rh D immunization in Rh D- women and subsequent hemolytic disease in Rh D+ infants is widespread, but has led to shortages of the anti-D Ig. With the aim of substituting monoclonal anti-D for Rh D prophylaxis, we have compared the abilities of monoclonal and polyclonal anti-D to clear Rh D+ red blood cells (RBCs) infused into Rh D- male volunteers and t...